Project Description

OxyFlo & OxyFloPro

제품 소개

OxyFlo는 3세대 Laser-Doppler 기반의 조직 혈류 측정 장비입니다.
실시간으로 지속적인 혈류를 측정하기 때문에, 급성 실험 모델에서 조직 혈류 변화를 관찰하는 데에 매우 이상적입니다.
다양한 프로브 유형을 지원하여 침습 또는 비침습 조직의 혈류 측정을 모두 필요로 하는 다양한 application를 지원합니다.

Application

•Blood flow monitoring in peripheral vascular disorder
•Cerebral perfusion monitoring in models of stroke and brain injury
•Tumor perfusion monitoring / angiogenesis
•Blood flow in free flaps and pedicle flaps
•Wound healing
•Gastroenterology

제품 특징

•artifact rejection 기술 특허를 통해 혈류 신호 내의 motion artifact 혹은 센서의 움직임으로 인한 spike 등을 효과적으로 제거하므로, 데이터의 정확한 측정이 가능합니다.
•digital과 graphic의 두 가지 방식의 데이터가 140° viewing-angle screen에 표시됩니다.
•2-channel 혹은 4-channel 모델로 연결하여 사용이 가능합니다.
•OxyLite와 연결하여 tissue oxygenation과 blood flow 및 temperature를 동시에 측정(combined sensor)하는 multi-parameter motoring이 가능합니다.

Single-channel monitoring
-Uncompromised reliability
-Measurements in acute experimental models

Multi-channel monitoring
-Uncompromised reliability
-Enhanced productivity & features

Data Examples
A model of Middle Cerebral Artery Occlusion in rat. 이 값은 blood perfusion units (BPU) 로 보여집니다.

Dedicated protective case
재사용 가능한 다양한 종류의 fibre-optic probe는 안전한 보관을 위해 전용 보호 케이스에 제공됩니다.

제품사양

GENERAL
Dimensions OxyFlo: 95mm (H) x 290mm (W) x 260mm (D)
OxyFlo Pro: 150mm (H) x 310mm (W) x 280mm (D)
Weight OxyLite: 2kg / 4.5lbs
OxyLite Pro: 4kg / 9lbs
Operating temperature 10~30°C
Operating humidity 0~70% (non-condensing)
Power requirements OxyFlo: VAC 100-240V, 50-60Hz, 30W max
OxyFlo Pro: External PSU (100-240V / 47-63 Hz), 40W max
Fuse rating OxyFlo: 2 x T1.6A
OxyFlo Pro: Not applicable
Number of sensors supported
/Number of channels
OxyFlo: 1
OxyFlo Pro: 2
OxyFlo Pro XL: 4
Display OxyFlo: 40 characters alphanumeric OLED
OxyFlo Pro: High contrast 800 x 480 LCD touch-screen
Instrument configuration OxyFlo: Via function button at the rear
OxyFlo Pro: Via touch-screen display
Analogue voltage outputs OxyFlo: 2 x male BNC connectors (2 outputs)
OxyFlo Pro: 1 x 15-pin D-type (4 outputs)
OxyFlo Pro XL: 2 x 15-pin D-type (8 outputs)
Laser type Temperature-stabilized semi-conductor laser diode
Laser wavelength 785 ±10nm
Laser classification Class 1 (EN 60825-1:1994, 21 CFR 1040.10 and 1040.11)
Laser power <0.5mW from probe tip/underside
Digital output USB type B interface for data recording to LabChart software (PC only)
Analogue output OxyFlo: 2 x BNC connectors for data recording (0-5V)
OxyFlo Pro: 15-pin D-connector interface for data recording via BNC adapter cable (0-5V)
PERFORMANCE
Mode of operation Laser Doppler flowmetry
Measurement units (displayed) 0~9999 BPU (blood perfusion units)
Stability of reading ±5%
Sampling rate 200Hz
Measurement averaging 200ms (Flow); 5ms (Raw); 5s (ART); 200ms (Backscatter), rolling
Display update interval (numerical) 2s (5s rolling averaged)
Probe identification Automatic; monitor stores one-time calibration
Probe calibration Factory or user-calibrated using Oxford Optronix motility standard
Probe shelf-life Unlimited
Zeroing Automatic, controlled
Default analogue data output range 0~5V (=0~5000 BPU or 0~100% Backscatter)
Analogue data output rate 65Hz

주문정보

제품번호 품명 규격 제조사 비고
OXYFLO OXYFLO
1 Channel microvascular blood flow monitor
set Oxford Optronix Body only
OXYFLO PRO OXYFLO PRO
2 Channel microvascular blood flow monitor
set Oxford Optronix Body only
OXYFLO PRO XL OXYFLO PRO XL
4 Channel microvascular blood flow monitor
set Oxford Optronix Body only
Blood Flow (LDF) Probes (for OxyFlo and OxyFlo Pro monitors; 3 m length unless stated)
MSP100NX Standard surface blood flow probe (17 mm diam.) ea Oxford Optronix
MSP110NX Digit surface blood flow probe (17 mm diam.) ea Oxford Optronix
MSP300NX Miniature surface blood flow probe (suturable, 12 mm diam.) ea Oxford Optronix
MSP310NX Miniature surface blood flow probe (non-suturable, 12 mm diam.) ea Oxford Optronix
MNP100NX Standard needle blood flow probe (30 mm needle, 1 mm diam.) ea Oxford Optronix
MNP100NX-3/10 Needle blood flow probe for MCAO (10 mm needle, 1 mm diam.) ea Oxford Optronix
MNP110NX Fine needle blood flow probe (30 mm needle, 0.5 mm diam.) ea Oxford Optronix
MNP150NX Bent tip blood flow needle probe (30 mm needle, 1 mm diam.) ea Oxford Optronix
Accessories
CAL KIT Calibration kit for LDF probes and MSFD NX adapter set Oxford Optronix
MSP140AR Double-sided adhesive rings for surface LDF probes. Pack of 200 pack Oxford Optronix
MH-05 Miniature holders for MNP100XP probe (5 mm diam.). Pack of 5 pack Oxford Optronix
MH-10 Miniature holders for MNP100XP probe (10 mm diam.). Pack of 5 pack Oxford Optronix
LabChart® Pro LabChart® Pro acquisition software (PC/Windows® only),
incl. 1 user license, 5 years free updates, USB cable(s)
software Oxford Optronix

Blood flow probes for OxyFlo™ and OxyFlo™ Pro

Surface Blood Flow Probes

MSP100NX – Standard probe for blood flow from tissue surfaces
Ideal for measurements of microvascular blood flow on tissue surfaces.
Tissue attachment via double-sided adhesive rings (product code ‘MSP140AR’).
MSP110NX – Digit probe for blood flow from rounded surfaces
Ideal for measuring cutaneous blood flow in the digits.
Tissue attachment via double-sided adhesive rings (product code ‘MSP140AR’).
MSP300NX – Miniature probe for blood flow from tissue surfaces (suturable)
Suitable for non-invasive tissue surface blood flow monitoring and for semi-invasive monitoring of blood flow from muscle and internal organ surfaces.
Tissue attachment via double-sided adhesive rings (product code ‘MSP140AR’) or by suture.
MSP310NX – Miniature probe for blood flow from tissue surfaces (non-suturable)
Suitable for non-invasive tissue surface blood flow monitoring and for semi-invasive monitoring of blood flow from muscle and internal organ surfaces.
Tissue attachment via double-sided adhesive rings (product code ‘MSP140AR’ see Accessories)


Needle Blood Flow Probes

MNP100NX – Standard needle blood flow probe
Suitable for invasive blood flow measurements or non-invasive blood flow measurements from tissue surfaces.
Typically positioned using an external clamp.
MNP100NX-3/10 – Standard needle blood flow probe for MCAO
Specifically conceived for cerebral microvascular blood flow measurements in MCAO and stroke applications.
Typically positioned using an external clamp or using dedicated miniature holders (product codes ‘MH-10’ and ‘MH-05’, see Accessories).
MNP110NX – Fine needle blood flow probe
Suitable for minimal tissue trauma during invasive insertion and is frequently used for measuring microvascular blood flow within a muscle, tumours, internal organs and brain tissue.
Typically positioned using an external clamp
MNP150NX – Bent-tip needle blood flow probe
An angled probe tip facilitates blood flow measurements in specialist applications such as gingiva and nasal mucosa.
Typically positioned using an external clamp.

악세서리

LabChart® Pro
옵션 소프트웨어인 LabChart® Pro를 사용하면 본체의 후면에 있는 전용 USB 출력을 통해 실시간 측정치를 PC로 direct streaming 가능합니다.

Calibration kit for blood flow probes
프로브을 별도로 주문시에만 필요하며, 본체와 함께 제공되는 프로브는 공장에서 사전 보정 된 상태로 공급됩니다.

Adhesive rings
surface blood flow probe를 피부에 고정하는 데 사용되는 양면 접착 링입니다.  200 개로 판매됩니다.

Miniature needle probe holders
MNP100NX-3 / 10 needle probe와 함께 사용하기 위한 소형 홀더입니다. 5mm 또는 10mm 직경으로 제공되며 5 개 팩으로 판매됩니다.

Articles

Daneva Z, Dempsey SK, Ahmad A, Li N, Li P-1L and Ritter JK (2019). Diuretic, natriuretic, and vasodepressor activity of a lipid fraction enhanced in medium of cultured mouse medullary interstitial cells by a selective FAAH inhibitor.
JPET Fast Forward DOI: 10.1124/jpet.118.252320

Ganesh T, Zakher , Estrada M and  Cheng HM (2019). Assessment of microvascular dysfunction in acute limb ischemia-reperfusion injury.
J Magn Reson Imaging 49(4), 1174-118

McBride DW Reis C, Zhang JH, Applegate R 2nd and Tang J (2018). Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via α1-Adrenoceptor-Protein Kinase Cε-Endothelial NO Synthase Pathway in Rats.
J Am Heart Assoc:7(7). pii: e007105

McBride DW, Wu G, Nowrangi D, Flores JJ, Hui L, Krafft PR and Zhang JH (2018). Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion.
Transl Stroke Res 9(2), 185-198

Nakamura S, Walker DW and Wong FY (2017).  Cerebral haemodynamic response to somatosensory stimulation in near-term fetal sheep.
J Physiol 595(4), 1289-1303

Shepherd J, Fisher M, Welford A, McDonald DM, Kanthou C and Tozer GM (2017). The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate.
Oncotarget 8(56), 95648-95661

Document

제품자료 OxyFlo flyer 2017a-BioD.pdf Download Size : 1.38Mb
제품 매뉴얼 OxyFlo User Manual v1.1.pdf Download Size : 2.02Mb
제품 매뉴얼 OxyFlo Pro User Manual v1.1.pdf Download Size : 4.52Mb