Project Description

OxyFlo & OxyFloPro

제품 소개

OxyFlo는 3세대 Laser-Doppler 방식의 실시간 조직 혈류 모니터링 장비입니다.
(혈류량을 확인하는 것이 아니라 ‘혈류 흐름의 변화’를 보는 장비입니다.)
급성 실험 모델에서 혈류 변화를 관찰하는 데에 매우 이상적이며, 침습 또는 비침습 조직의 혈류 측정을 위한 다양한 프로브 유형을 지원합니다.

측정치는 0 ~ 9999 BPU (blood perfusion units) 까지 display에 표시됩니다.
별도의 데이터 저장장치와 옵션 소프트웨어인 LabChart® Pro data recording and analysis software 를 사용하면,
모니터의 후면에 있는 전용 USB 출력을 통해 실시간 측정치를 PC로 direct streaming도 가능합니다.

Application

•Blood flow monitoring in peripheral vascular disorder
•Cerebral perfusion monitoring in models of stroke and brain injury
•Tumor perfusion monitoring / angiogenesis
•Blood flow in free flaps and pedicle flaps
•Wound healing
•Gastroenterology

제품 특징

• 3세대 레이저 도플러 조직 혈류 모니터
• 타의 추종을 불허하는 사용 편의성
• 지속적인 실시간 조직내 혈류 측정
• 센서의 움직임으로 인한 Signal artifact 억제
• 최대 4개 위치에서 동시에 측정
• 뛰어난 정확도, 안정성 및 성능
• 직관적인 터치스크린 컨트롤

Single-channel monitoring
-Uncompromised reliability
-Measurements in acute experimental models

Multi-channel monitoring
-Uncompromised reliability
-Enhanced productivity & features

Data Examples ( LabChart® Pro)
A model of Middle Cerebral Artery Occlusion in rat. 이 값은 blood perfusion units (BPU) 로 보여집니다.

Dedicated protective case
재사용 가능한 다양한 종류의 fibre-optic probe는 안전한 보관을 위해 전용 보호 케이스에 제공됩니다.

제품사양

GENERAL
Dimensions OxyFlo: 95mm (H) x 290mm (W) x 260mm (D)
OxyFlo Pro: 150mm (H) x 310mm (W) x 280mm (D)
Weight OxyLite: 2kg / 4.5lbs
OxyLite Pro: 4kg / 9lbs
Operating temperature 10~30°C
Operating humidity 0~70% (non-condensing)
Power requirements OxyFlo: VAC 100-240V, 50-60Hz, 30W max
OxyFlo Pro: External PSU (100-240V / 47-63 Hz), 40W max
Fuse rating OxyFlo: 2 x T1.6A
OxyFlo Pro: Not applicable
Number of sensors supported
/Number of channels
OxyFlo: 1
OxyFlo Pro: 2
OxyFlo Pro XL: 4
Display OxyFlo: 40 characters alphanumeric OLED
OxyFlo Pro: High contrast 800 x 480 LCD touch-screen
Instrument configuration OxyFlo: Via function button at the rear
OxyFlo Pro: Via touch-screen display
Analogue voltage outputs OxyFlo: 2 x male BNC connectors (2 outputs)
OxyFlo Pro: 1 x 15-pin D-type (4 outputs)
OxyFlo Pro XL: 2 x 15-pin D-type (8 outputs)
Laser type Temperature-stabilized semi-conductor laser diode
Laser wavelength 785 ±10nm
Laser classification Class 1 (EN 60825-1:1994, 21 CFR 1040.10 and 1040.11)
Laser power <0.5mW from probe tip/underside
Digital output USB type B interface for data recording to LabChart software (PC only)
Analogue output OxyFlo: 2 x BNC connectors for data recording (0-5V)
OxyFlo Pro: 15-pin D-connector interface for data recording via BNC adapter cable (0-5V)
PERFORMANCE
Mode of operation Laser Doppler flowmetry
Measurement units (displayed) 0~9999 BPU (blood perfusion units)
Stability of reading ±5%
Sampling rate 200Hz
Measurement averaging 200ms (Flow); 5ms (Raw); 5s (ART); 200ms (Backscatter), rolling
Display update interval (numerical) 2s (5s rolling averaged)
Probe identification Automatic; monitor stores one-time calibration
Probe calibration Factory or user-calibrated using Oxford Optronix motility standard
Probe shelf-life Unlimited
Zeroing Automatic, controlled
Default analogue data output range 0~5V (=0~5000 BPU or 0~100% Backscatter)
Analogue data output rate 65Hz

Blood flow probes for OxyFlo and OxyFloPro

Surface Blood Flow Probes
Tissue attachment via double-sided adhesive rings (product code ‘MSP140AR’) or by suture.

MSP100NX-Standard probe for blood flow from tissue surfaces
for measurements of microvascular blood flow on tissue surfaces
MSP110NX-Digit probe for blood flow from rounded surfaces
for measuring cutaneous blood flow in the digits
MSP300NX-Miniature probe for blood flow from tissue surfaces (suturable)
for non-invasive tissue surface blood flow monitoring
for semi-invasive monitoring of blood flow from muscle and internal organ surfaces
MSP310NX-Miniature probe for blood flow from tissue surfaces (non-suturable)
for non-invasive tissue surface blood flow monitoring
for semi-invasive monitoring of blood flow from muscle and internal organ surfaces


Needle Blood Flow Probes
Typically positioned using an external clamp

MNP100NX-Standard needle blood flow probe
for invasive blood flow measurements or non-invasive blood flow measurements from tissue surfaces
MNP100NX-3/10-Standard needle blood flow probe for MCAO
for cerebral microvascular blood flow measurements in MCAO and stroke applications
MNP110NX-Fine needle blood flow probe
for minimal tissue trauma during invasive insertion
for measuring microvascular blood flow within the muscle, tumors, internal organs, and brain tissue
MNP150NX-Bent-tip needle blood flow probe
for specialist applications such as gingiva and nasal mucosa


Specialist Blood Flow Probes

MSF100NX– Single-fibre implantable blood flow probe
for chronic implantation, the MSF100NX can be directly inserted into tissue using a standard 22G i.d. cannula
* Flow measurements are made by attaching the MSF Driver
NX-BF/F-Bare-fibre type blood flow probe
for direct insertion into tissue (via catheter or cannula)
for measurement of microvascular blood flow from deeper tissue regions.
* Tissue placement via introducer (e.g. Angiocath®)

Optional Accessory

ValueADC 아날로그 데이터 저장장치
The 12-input analog data acquisition module

PowerLab 4/26 디지털 데이터 저장 장치
Economically priced 4 channel data acquisition featuring 4 analog inputs with LabChart® Pro

LabChart® Pro
옵션 소프트웨어인 LabChart® Pro를 사용하면 본체의 후면에 있는 전용 USB 출력을 통해 실시간 측정치를 PC로 direct streaming 가능합니다.

Calibration kit for blood flow probes
프로브을 별도로 주문시에만 필요하며, 본체와 함께 제공되는 프로브는 공장에서 사전 보정 된 상태로 공급됩니다.

Adhesive rings
surface blood flow probe를 피부에 고정하는 데 사용되는 양면 접착 링입니다.  200 개로 판매됩니다.

Miniature needle probe holders
MNP100NX-3 / 10 needle probe와 함께 사용하기 위한 소형 홀더입니다. 5mm 또는 10mm 직경으로 제공되며 5 개 팩으로 판매됩니다.

Articles

Journal-citations-oxyflo.pdf

Select recent journal articles:

Daneva Z, Dempsey SK, Ahmad A, Li N, Li P-1L and Ritter JK (2019). Diuretic, natriuretic, and vasodepressor activity of a lipid fraction enhanced in medium of cultured mouse medullary interstitial cells by a selective FAAH inhibitor.
JPET Fast Forward DOI: 10.1124/jpet.118.252320

Ganesh T, Zakher , Estrada M and  Cheng HM (2019). Assessment of microvascular dysfunction in acute limb ischemia-reperfusion injury.
J Magn Reson Imaging 49(4), 1174-118

McBride DW Reis C, Zhang JH, Applegate R 2nd and Tang J (2018). Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via α1-Adrenoceptor-Protein Kinase Cε-Endothelial NO Synthase Pathway in Rats.
J Am Heart Assoc:7(7). pii: e007105

McBride DW, Wu G, Nowrangi D, Flores JJ, Hui L, Krafft PR and Zhang JH (2018). Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion.
Transl Stroke Res 9(2), 185-198

Nakamura S, Walker DW and Wong FY (2017).  Cerebral haemodynamic response to somatosensory stimulation in near-term fetal sheep.
J Physiol 595(4), 1289-1303

Shepherd J, Fisher M, Welford A, McDonald DM, Kanthou C and Tozer GM (2017). The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate.
Oncotarget 8(56), 95648-95661

주문정보

제품번호 품명 규격 제조사 비고
OXYFLO OXYFLO
1 Channel microvascular blood flow monitor
set Oxford Optronix Body only
OXYFLO PRO OXYFLO PRO
2 Channel microvascular blood flow monitor
set Oxford Optronix Body only
OXYFLO PRO XL OXYFLO PRO XL
4 Channel microvascular blood flow monitor
set Oxford Optronix Body only
Blood Flow (LDF) Probes (for OxyFlo and OxyFlo Pro monitors; 3 m length unless stated)
MSP100NX Standard surface blood flow probe (17 mm diam.) ea Oxford Optronix
MSP110NX Digit surface blood flow probe (17 mm diam.) ea Oxford Optronix
MSP300NX Miniature surface blood flow probe (suturable, 12 mm diam.) ea Oxford Optronix
MSP310NX Miniature surface blood flow probe (non-suturable, 12 mm diam.) ea Oxford Optronix
MNP100NX Standard needle blood flow probe (30 mm needle, 1 mm diam.) ea Oxford Optronix
MNP100NX-3/10 Needle blood flow probe for MCAO (10 mm needle, 1 mm diam.) ea Oxford Optronix
MNP110NX Fine needle blood flow probe (30 mm needle, 0.5 mm diam.) ea Oxford Optronix
MNP150NX Bent tip blood flow needle probe (30 mm needle, 1 mm diam.) ea Oxford Optronix
Accessories
CAL KIT Calibration kit for LDF probes and MSFD NX adapter set Oxford Optronix
MSP140AR Double-sided adhesive rings for surface LDF probes. Pack of 200 pack Oxford Optronix
MH-05 Miniature holders for MNP100XP probe (5 mm diam.). Pack of 5 pack Oxford Optronix
MH-10 Miniature holders for MNP100XP probe (10 mm diam.). Pack of 5 pack Oxford Optronix
LabChart® Pro LabChart® Pro acquisition software (PC/Windows® only),
incl. 1 user license, 5 years free updates, USB cable(s)
software ADInstruments
POWERLAB 4/26 4 Channel data recorder (PC/Mac),
incl. LabChart® software, 5 years free updates
unit ADInstruments
POWERLAB 8/35 8 Channel data recorder (PC/Mac),
incl. LabChart® software, 5 years free updates
unit ADInstruments
POWERLAB 16/35 16 Channel data recorder (PC/Mac),
incl. LabChart® software, 5 years free updates
unit ADInstruments

Document

제품자료 OxyFlo flyer 2017a-BioD.pdf Download Size : 1.38Mb
제품 매뉴얼 OxyFlo User Manual v1.1.pdf Download Size : 2.02Mb
제품 매뉴얼 OxyFlo Pro User Manual v1.1.pdf Download Size : 4.52Mb