Project Description
TargetMol Inhibitors
제품 소개
TargetMol은 5,000개 이상의 Compounds와 60 type 이상의 library를 제공하는 Drug screen & Pharmacological research 전문 기업입니다.
Small Molecule Inhibitors
Small molecule inhibitors은 target proteins에 결합하여 생물학적 활성을 감소시킬 수 있어 생물학 및 약리학 관련 연구에서 널리 활용되고 있습니다.
이들은 세포 주기 제어 및 유사분열에서 신호 전달 경로 및 유전자 발현에 이르기까지 다양한 세포 성장 과정을 조절하는 데 관여하고 있기 때문에 최근 생명 과학 연구에서 중요한 도구가 되고 있습니다.
제품특징
• 쉬운 조작성
• 동물 실험에 적용 가능
• 좋은 세포막 투과성
• 높은 안정성
Signaling Pathways
| •Angiogenesis •Apoptosis •Autophagy •Cell Cycle/Checkpoint •Chromatin/Epigenetic •Cytoskeletal Signaling •DNA Damage/DNA Repair •Endocrinology/Hormones •GPCR/G Protein •Immunology/Inflammation •JAK/STAT signaling •MAPK |
•Membrane transporter/Ion channel •Metabolism •Microbiology/Virology •Neuroscience •NF-Κb •Oxidation-reduction •PI3K/Akt/mTOR signaling •Proteases/Proteasome •Stem Cells •Tyrosine Kinase/Adaptors •Ubiquitination •Others |
제품상세
ALK (58), Bcr-Abl (65), BTK (46), EGFR (192), FAK (26), FGFR (74), FLT (89), HER (30), HIF (41), JAK (112), PDGFR (81), Src (92), Syk (26), VDA (2), VEGFR (161).
Apoptosis inducer (6), ASK (5), BCL (138), Caspase (142), C-RET (33), Ferroptosis (12), FOXO1 (2), IAP (15), Mdm2 (33), P53 (57), PD-1/PD-L1 (11), PERK (11), Survivin (4), TNF (224), Fas/FasL (2), Apoptosis (116), RIP kinase (3), OXPHOS (3).
Autophagy (167), CXCR (45), LRRK2 (21), Lysosomal autophagy (2), Mitophagy (5).
APC (2), Aurora Kinase (53), BMI-1 (6), CDK (218), Cell cycle arrest (4), Chk (29), C-Myc (21), DHFR (18), DNA/RNA Synthesis (324), DYRK (36), Ferroptosis (12), KSP (3), LIM Kinase (9), Nucleoside Antimetabolite… (18), PD-1/PD-L1 (11), PLK (74), Rho (19), ROCK (39), Serine/threonin kinase (19), Wee1 (3), Haspin Kinase (3), Deubiquitinase (4), Antifolate (3), IRE1 (6).
Aurora Kinase (53), DNA Methyltransferase (23), Epigenetic Reader Domain (158), HDAC (111), HIF (41), HIF/HIF Prolyl-Hydroxylas… (10), Histone Demethylase (55), Histone Methyltransferase (223), JAK (112), PARP (80), Pim (23), PKC (106), Sirtuin (44), Histone Acetyltransferase (76), MicroRNA (3), Histone Acetylation (1), PAD (5).
Akt (131), Bcr-Abl (65), Dynamin (5), FAK (26), Gap Junction Protein (9), HSP (67), Integrin (43), Kinesin (20), Microtubule Associated (91), PAK (14), PKC (106), ROCK (39), Wnt/beta-catenin (72), Arp2/3 Complex (0), Myosin (3).
ATM/ATR (61), BMI-1 (6), DHFR (18), DNA (6), DNA Alkylation (32), DNA gyrase (14), DNA/RNA Synthesis (324), DNA-PK (34), HDAC (111), MTH1 (7), Nucleoside Antimetabolite… (18), PARP (80), PPAR (131), Sirtuin (44), Telomerase (13), Topoisomerase (107), DNA Alkylator/Crosslinker (2), Deubiquitinase (4).
Androgen Receptor (75), Aromatase (15), Estrogen/progestogen Rece… (121), Glucocorticoid Receptor (69), GPR (75), LHRH (1), Opioid Receptor (94), RAAS (89), Reductase (27), Thyroid hormone receptor(… (22), Estrogen Receptor/ERR (6), Oxytocin Receptor (6).
5-HT Receptor (360), Adenosine Receptor (34), Adiponectin receptor (3), Adrenergic Receptor (232), Annexin A (5), Bombesin Receptor (4), Bradykinin Receptor (12), CAMP (35), Cannabinoid Receptor (42), CaSR (7), Cholecystokinin (10), CXCR (45), Dopamine Receptor (209), Endothelin Receptor (17), Glucagon Receptor (21), GNRH Receptor (20), GPCR19 (13), GPR (75), GRK (9), GTPase (7), Hedgehog/Smoothened (21), Histamine Receptor (144), LPA Receptor (12), Melatonin Receptor (2), Neurokinin receptor (33), Opioid Receptor (94), OX Receptor (19), PAFR (40), Prostaglandin Receptor (113), Protease-activated Recept… (25), Ras (45), S1P Receptor (32), SGLT (26), Sigma receptor (21), Somatostatin (4), Vasopressin Receptor (14), GHSR (12), Melanocortin Receptor (14), Neurotensin Receptor (7), Motilin Receptor (1), Melanin-concentrating Hor… (4), Neuropeptide Y Receptor (14), Leukotriene Receptor (1), EBI2/GPR183 (3), TSH Receptor (3), Oxytocin Receptor (6), Guanylate cyclase (7), CRFR (3), Apelin receptor (1).
AhR (21), Antiviral (42), Arginase (7), CCR (45), Cell wall (5), COX (298), CXCR (45), Gp120/CD4 (8), Histamine Receptor (144), IL Receptor (175), Immunology & Inflammation… (94), LTR (26), MALT (4), MRP (21), NADPH-oxidase (34), NOD (20), NOS (112), Nrf2 (46), PD-1/PD-L1 (11), PGE Synthase (5), Prostaglandin Receptor (113), ROS (130), TLR (55), Complement System (8), MyD88 (1), STING (13), NO Synthase (17), Thrombopoietin Receptor (2), NOD-like Receptor (NLR), (1), IRAK (5), Interleukin Related (0), Interleukin Related (4), Immunology & Inflammation… (0), FLAP (3), Cytokine release (0), Aryl Hydrocarbon Receptor (4), Reactive Oxygen Species (4), IFNAR (1).
EGFR (192), HER (30), JAK (112), Pim (23), STAT (90).
ERK (247), JNK (103), MAPK (81), MEK (49), MLK (10), MNK (4), P38 MAPK (119), Raf (75), Ras (45), S6 Kinase (29), TOPK (4).
Membrane transporter/Ion channel
ABC (14), ATPase (84), Calcium Channel (189), CFTR (15), CGRP Receptor (7), Chloride channel (21), CRM1 (7), GABA Receptor (145), Monoamine Transporter (9), Monocarboxylate transport… (8), Na-K-Cl cotransporter (3), NPC1L1 (7), OAT (3), OCT (5), P-gp (39), Potassium Channel (160), Proton pump (20), Sodium Channel (121), TRP/TRPV Channel (81), Anion Exchanger (1), VDAC (3), P2X Receptor (1), Na+/Ca2+ Exchanger (1), IGluR (7), HCN Channel (1), BCRP (4), Aquaporin (2).
Acetyl-CoA Carboxylase (9), AhR (21), Amino Acids and Derivativ… (24), Aminopeptidase (7), ATP Citrate Lyase (4), Calcium Channel (189), Carbonic Anhydrase (31), Carboxypeptidase(CPG2), (3), Casein Kinase (34), CETP (11), Decarboxylase (6), Dehydrogenase (120), DHFR (18), FAAH (20), Factor Xa (15), Fatty Acid Synthase (24), FXR (23), Glucokinase (89), GR (8), GSNOR (1), HIF/HIF Prolyl-Hydroxylas… (10), HMG-CoA Reductase (19), HSP (67), Hydrogenase (1), Hydroxylase (16), IDO (29), LDL (22), Lipase (14), Lipid (9), Lipoxygenase (49), Liver X Receptor (19), MAO (63), MPO (7), NADPH (20), NAMPT (10), P450 (141), PAI-1 (6), PDE (133), PED (2), Phosphatase (59), Phospholipase (41), Phosphorylase (8), PKM (85), PPAR (131), Procollagen C Proteinase (1), RAR/RXR (2), Reductase (27), Retinoid Receptor (29), ROR (20), Serine/threonin kinase (19), SGK (6), Thioredoxin (1), Transferase (33), Transporter (26), UGT (10), Vitamin (53), CPT (1), FABP (4), HCE (0), N-Acetylglucosaminyltrans… (1), Transaminase (2), Endogenous Metabolite (283), Xanthine Oxidase (7), Mitochondrial Metabolism (15), HCE(human carboxylesteras… (0), Glycosidase (0), Aconitase (1), Epoxide Hydrolase (1), Acyltransferase (5), Neprilysin (5), Electron transport (2), Stilbene oxidase (2), Stearoyl-CoA Desaturase (… (1), Reactive Oxygen Species (4), NEDD8 (1), MAGL (1), Isocitrate Dehydrogenase … (1), Indoleamine 2,3-Dioxygena… (2), Hexokinase (5), Glutathione Peroxidase (2), Adenosine deaminase (1).
Antibacterial (298), Antibiotic (181), Antifection (476), Antifungal (94), CCR (45), GluCls (3), HBV (40), HCV Protease (75), HIV Protease (164), HSV (37), Influenza Virus (47), Integrase (5), Reverse Transcriptase (18), Ribosome (34), Parasite (51), Anti-infection (5), RSV (5), SARS-CoV (11), Virus Protease (1), Bacterial (0).
5-HT Receptor (360), AChR (354), Adrenergic Receptor (232), BACE (29), Beta Amyloid (52), CaMK (27), COX (298), Dopamine Receptor (209), FAAH (20), GABA Receptor (145), Gamma-secretase (26), GluR (104), GlyT (7), Histamine Receptor (144), MAO (63), Neurokinin receptor (33), NMDAR (52), Norepinephrine (33), Opioid Receptor (94), OX Receptor (19), P2 Receptor (42), P-gp (39), Beta-Secretase (2), MT Receptor (6), Melanocortin Receptor (14), Neuropeptide Y Receptor (14), AChE (5), Serotonin Transporter (7), NMU2R (1), Monoamine Oxidase (3), IGluR (7), Adenylyl cyclase (1).
IκB/IKK (64), NF-κB (271), NOD (20), RIP kinase (3), IRAK (5), Reactive Oxygen Species (4).
Antioxidant (120), CAT (9), Free radical scavengers (7), Glutathione reductase (4), GPX (3), GST (5).
Akt (131), AMPK (71), ATM/ATR (61), DNA-PK (34), GSK-3 (69), MELK (5), MTOR (98), PDK (17), PI3K (218), PTEN (5), S6 Kinase (29), SIK (3), PI4K (3).
Acetyl-CoA Carboxylase ATP Citrate Lyase (4), Caspase (142), Cysteine Protease (39), DPP-4 (20), Gamma-secretase (26), Glutaminase (3), HCV Protease (75), HIV Protease (164), MMP (87), Proteasome (38), Serine Protease (32), Thrombin (32), Tyrosinase (80), Acyltransferase (5).
Casein Kinase (34), Gamma-secretase (26), GSK-3 (69), Hedgehog/Smoothened (21), Hippo pathway (4), JAK (112), Porcupine (5), ROCK (39), STAT (90), TGF-beta/Smad (34), Wnt/beta-catenin (72), YAP (1), TACC (2), Stemness kinase (1), Smo (4).
ACK (3), ALK (58), Bcr-Abl (65), BTK (46), C-Fms (19), C-Kit (66), C-Met/HGFR (67), C-RET (33), CSF-1R (13), DYRK (36), EGFR (192), Ephrin Receptor (10), FAK (26), FGFR (74), FLT (89), Hck (3), HER (30), IGF-1R (26), PDGFR (81), PKA (48), PYK2 (4), Src (92), Syk (26), TAM Receptor (34), Tie-2 (7), Trk receptor (33), Tyrosine Kinases (47), VEGFR (161), Discoidin Domain Receptor… (7).
DUB (33), E2 conjugating (0), P97 (7), Proteasome (38), E1/E2/E3 Enzyme (16).
ACAT (8), Advanced glycation end pr… (4), Decarboxylase (6), DprE1 (4), Others (14991), Platelet aggregation (6), Wnk (2), BVDV (0), Keap1-Nrf (1), NKCC (0), Salt-Inducible Kinase (0), PTP1B (0), Progesterone Receptor (1), Thyroid Hormone Receptor (1), Fer/FerT kinase (0), CYP19A1 (0), Cathepsin B (0), PGK (2), Streptokinase (34), Hepatitis C virus NS3 pro… (1), Vaccinia virus (1), High-affinity choline tra… (1), Genome polyprotein (1), Epstein-Barr nuclear anti… (1), Vesicular stomatitis viru… (1), Ataxin (174), 3C-like protease (1), Autoinducer 1 sensor kina… (1), Human immunodeficiency vi… (5), Human herpesvirus 1 strai… (1), Voltage-gated potassium c… (1), Malme-3M (1), Serotonin 2a (5-HT2a), rec… (1), Saccharomyces cerevisiae (2), Enoyl-acyl carrier reduct… (2), Putative uncharacterized … (1), Egl nine homolog 3 (1), Paracentrotus lividus (1), SNB-75 (1), Candida albicans (1), NIH3T3 (1), Muscarinic acetylcholine … (1), Cytochrome P450 2D6 (1), Ubiquitin-conjugating enz… (1), Staphylococcus aureus (3), Giardia (2), Putative fructose-1,6-bis… (2), Trypanosoma brucei rhodes… (1), Cannabinoid CB2 receptor (1), Trypanosoma brucei brucei (6), Toxoplasma gondii RH (1), Glycine transporter 2 (1), Relaxin receptor 1 (1), Phosphoglycerate kinase, … (8), Nucleic Acid (2), ORF 73 (1), Large T antigen (4), Human parainfluenza virus… (1), Phosphotyrosine-protein p… (1), Enoyl-[acyl-carrier-prote… (1), Streptokinase A (21), Mycobacterium bovis BCG (4), Shiga toxin (2), HL-60 (1), INS1 (1), Smoothened homolog (1), Casein kinase I delta (0), Isoprenylcysteine carboxy… (1), Phosphodiesterase 6D (1), Excitatory amino acid tra… (1), Heat shock factor protein… (1), Sentrin-specific protease… (1), Phosphodiesterase 10A (1), Tyrosine-protein kinase S… (0), Formyl peptide receptor 1 (2), Transient receptor potent… (2), Macrophage migration inhi… (1), Intestinal alkaline phosp… (2), Cytochrome P450 17A1 (1), Butyrylcholinesterase (2), Zinc finger protein GLI1 (1), Heparanase (1), 1-acylglycerol-3-phosphat… (1), Voltage-gated T-type calc… (2), DNA dC->dU-editing enzyme… (2), Kappa opioid receptor (1), Fructose-bisphosphate ald… (1), Cytochrome P450 3A4 (2), Estrogen receptor alpha (2), Voltage-gated T-type calc… (3), C-C chemokine receptor ty… (2), A498 (1), MRC5 (2), Trace amine-associated re… (4), MDA-MB-468 (1), MCF7 (1), Prostaglandin E synthase (2), Fatty acid transport prot… (1), Flap endonuclease 1 (2), Matrix metalloproteinase-… (1), Nociceptin receptor (1), Long-chain fatty acid tra… (1), Glycogen synthase kinase-… (0), SF-539 (1), Peripheral-type benzodiaz… (1), HeLa (2), SK-BR-3 (1), Thioredoxin reductase 1, … (5), Mus musculus (2), Tumour suppressor p53/onc… (1), Neutrophils (2), Breast cancer type 1 susc… (6), Alpha-synuclein (5), SNB-19 (1), No relevant target (2), HepG2 (4), RAW264.7 (2), Menin/Histone-lysine N-me… (15), UO-31 (1), DNA polymerase eta (6), Paired box protein Pax-8 (2), DNA dC->dU-editing enzyme… (18), Mitogen-activated protein… (1), A549 (1), DNA polymerase iota (36), Cavia porcellus (3), Tankyrase-2 (2), Plasmodium falciparum (419), Protein-glutamine gamma-g… (1), Cytochrome P450 19A1 (2), MOLT-4 (1), Leukocyte elastase (1), Xanthine dehydrogenase (1), RXF 393 (2), SK-MEL-2 (1), Cytochrome P450 2C9 (2), ATP-dependent molecular c… (5), Phosphodiesterase 5A (2), T98G (4), PI3-kinase p110-alpha sub… (0), Isocitrate dehydrogenase … (5), Cyclooxygenase-2 (2), MIF/CD74 (Macrophage migr… (1), Runt-related transcriptio… (5), GABA-A receptor; anion ch… (0), Cytochrome P450 2C19 (2), NCI-H460 (1), OVCAR-5 (1), Vascular endothelial grow… (0), Aorta (2), Ubiquitin carboxyl-termin… (1), Vero (1), Prostanoid EP2 receptor (1), Peptidyl-prolyl cis-trans… (1), TAR DNA-binding protein 4… (202), Cytochrome P450 1A2 (5), Mothers against decapenta… (435), Fibroblast growth factor … (1), MicroRNA 21 (105), Luciferin 4-monooxygenase (35), FAD-linked sulfhydryl oxi… (9), Signal transducer and act… (1), XF498 (2), PI3-kinase p110-delta sub… (0), HEK293 (557), Histone-lysine N-methyltr… (4), Monoamine oxidase B (5), Estradiol 17-beta-dehydro… (1), Tyrosine-protein kinase A… (0), Estrogen receptor beta (1), Aldo-keto-reductase famil… (2), Neurokinin 3 receptor (4), Cytochrome P450 11B2 (1), Sigma-1 receptor (2), Sigma opioid receptor (1), Endothelin-converting enz… (1), Testis-specific androgen-… (2), Anthrax lethal factor (9), Kinesin-like protein 1 (2), Peroxisome proliferator-a… (1), Tyrosyl-DNA phosphodieste… (3), Serotonin 2c (5-HT2c), rec… (4), Niemann-Pick C1 protein (17), Serotonin 6 (5-HT6), recep… (14), Ras-related protein Rab-9… (26), Adenosine A1 receptor (3), Adenosylmethionine-8-amin… (2), Inosine-5′-monophosphate … (1), Bromodomain adjacent to z… (11), Lysine-specific demethyla… (0), G-protein coupled recepto… (1), Dopamine D2 receptor (3), Glutaminase kidney isofor… (5), Lipoxin A4 receptor (3), Arachidonate 15-lipoxygen… (2), Melanin-concentrating hor… (1), Aberrant vpr protein (23), Elongation of very long c… (1), Alkaline phosphatase, tis… (3), Beta-glucocerebrosidase (22), Alpha-galactosidase A (5), Nonstructural protein 1 (136), Vanilloid receptor (2), Metabotropic glutamate re… (8), 6-phospho-1-fructokinase (0), Neuropeptide S receptor (14), 4′-phosphopantetheinyl tr… (5), Tumor susceptibility gene… (3), Lysine-specific demethyla… (2), MAP kinase ERK2 (1), FK506 binding protein 12 (124), P-glycoprotein 1 (5), ATP-dependent DNA helicas… (9), Endoplasmic reticulum-ass… (7), Ecdysone receptor (1), Cholesteryl ester transfe… (2), Huntingtin (77), Lethal(3),malignant brain … (10), 15-hydroxyprostaglandin d… (10), Short transient receptor … (19), Transcriptional regulator… (5), Aldehyde dehydrogenase di… (1), ATP-dependent Clp proteas… (111), Thioredoxin glutathione r… (24), Cellular tumor antigen p5… (560), Cannabinoid CB1 receptor (8), ATP-binding cassette sub-… (1), Aldehyde dehydrogenase 1A… (58), TGF-beta receptor type II (2), Histone acetyltransferase… (25), Glucagon-like peptide 1 r… (213), Glycoprotein hormones alp… (110), Tyrosine-protein kinase r… (1), Survival motor neuron pro… (73), Histone-lysine N-methyltr… (68), Microtubule-associated pr… (613), Prelamin-A/C (542), Lysosomal alpha-glucosida… (42), Geminin (246), Arachidonate 15-lipoxygen… (5), Epoxide hydratase (3), Beta-2 adrenergic recepto… (6), Inositol monophosphatase … (111), Thyroid hormone receptor … (314), Thyroid stimulating hormo… (50), Dihydrofolate reductase (1), G protein-coupled recepto… (4), Beta-lactamase AmpC (613), Ataxin-2 (215), Hypoxia-inducible factor … (4), Nuclear factor erythroid … (389), Cruzipain (33), Guanine nucleotide-bindin… (164), Serine-protein kinase ATM (2), Pyruvate kinase isozymes … (2), Nuclear receptor ROR-gamm… (140), ATPase family AAA domain-… (113) .
Document
| 제품 자료 | Inhabitors of Signaling Pathways.pdf | Upload date: 2121.09.28 |