Project Description
Calixar Membrane Proteins
제품 소개
Calixar 사는 막단백질 (GPCRs, Ion Channels, Transporters, Receptors, Anchors and Viral Proteins)의 원래 구조와 기능을 잘 보존하면서 분리하여 항체나 백신의 개발, 그리고 이를 활용한 새로운 치료 약물의 개발에 많은 도움을 주고 있는 이 분야 최고의 전문 기업입니다.
제품 특징
• Better Discovery
특정 형태에 얽매이지 않고 신뢰할 수 있고 효율적인 약물 및 항체 탐색
• Made for Pharma/Biotech
고품질 막 단백질로 제약, 생명 공학 회사 및 학술 팀의 응용 분야에 적합
• Any Life Science
Antibodies (Nanobodies, Scaffold proteins, Aptamers, Small molecules, 3D Structures
• Native Proteins
천연형, 야생형, 돌연변이 및 온전한 표적의 단백질 생산
• Proprietary Technology
고객을 위한 독점 기술과 전문성 제공 (7개의 특허군, 20개의 간행물)
• At any stage
모든 임상 단계에서 치료 약물 발견, 항체 개발 및 검증에 적합
Application
• Conformational antibody development
• Vaccine development
• High-throughput ligand screening
• Structure-based drug discovery
• Immunoassays
• Deorphanization projects
• Identification of relevant targets
• Expression of full-length membrane proteins
• Functional isolation and stabilization of targets
제품 사양
GPCR / A2A |
 GPCR / MT1 |
 Transporter / AcrB |
 Transporter / BmrA |
 Ion Channels / KCC2 |
 Ion Channels / M2 |
| GPCRs | A2A | MT1 |
| Target name | Adenosine receptor (A2A receptor) | Melatonin receptor type 1A (MT1) |
| Catalogue number | PP1 | PP2 |
| Class | GPCR Class A | GPCR Class A |
| Sequence | Full-length, wildtype sequence, with a N-terminus Strep tag II, 8xHis-tag, and TEV protease cleavage site. |
Full-length, wildtype sequence, with a N-terminus Strep tag II, 8xHis-tag, and TEV protease cleavage site. |
| Affinity Tag | His/Strep (both N-terminal) | Strepx2/His (both N-terminal) |
| Origin | Human (Homo sapiens) | Human (Homo sapiens) |
| Theor. MW | 47,7kDa | 44,8kDa |
| Accession # | P29274 (UniProt) | P48039 (UniProt |
| Shipment temperature | Dry Ice | Dry Ice |
| Storage conditions | Store at -80°C | Store at -80°C |
| Datasheet | A2A-Datasheet.pdf | MT1-Datasheet.pdf |
| Transporter | AcrB | BmrA |
| Target name | Multidrug efflux pump subunit AcrB | Multidrug resistance ABC transporter ATP-binding/permease protein (BmrA) |
| Catalogue number | PP4 | PP3 |
| Class | Multidrug efflux pump | Multidrug resistance ABC transporter |
| Sequence | Full-length, wildtype sequence, with a C-terminus, 6xHis-tag | Full-length, wildtype sequence, with a N-terminus 6xHis-tag. |
| Affinity Tag | His-tag (C-terminal) | His-tag (N-terminal) |
| Origin | Escherichia coli (strain K12) | Bacillus subtilis (strain 168) |
| Theor. MW | 114.6 kDa | 64.5 kDa |
| Accession # | P31224 (UniProt) | O06967 (UniProt) |
| Shipment temperature | Dry Ice | Dry Ice |
| Storage conditions | Store at -80°C | Store at -80°C |
| Datasheet | AcrB-datasheet.pdf | BmrA-Datasheet.pdf |
| Ion Channels | KCC2 | M2 |
| Target name | Coming soon | Coming soon |
| Catalogue number | Coming soon | Coming soon |
| Class | Coming soon | Coming soon |
| Sequence | Coming soon | Coming soon |
| Affinity Tag | Coming soon | Coming soon |
| Origin | Coming soon | Coming soon |
| Theor. MW | Coming soon | Coming soon |
| Accession # | Coming soon | Coming soon |
| Shipment temperature | Coming soon | Coming soon |
| Storage conditions | Coming soon | Coming soon |
| Datasheet | Coming soon | Coming soon |
Case Studies
1. Adenosine Receptor (A2A) – Calixar
2. ABC Transporter (BmrA) – Calixar
3. Bacteriorhodopsin – Calixar
4. Bcl-2 Associated Athanogene 3 (BAG3) – Calixar
5. Influenza Matrix Protein 2 (M2) – Calixar
6. Influenza A – H1N1 vaccinal preparation – Calixar
7. K-Cl co-transporter 2 (KCC2) – Calixar
8. Voltage-gated Sodium Channel (Nav1.7) – Calixar
Document
| 제품 자료 | A2A-Datasheet.pdf MT1-Datasheet.pdf AcrB-datasheet.pdf BmrA-Datasheet.pdf |
Upload date: 2021.10.07 |