Project Description

Calixar Membrane Proteins

제품 소개

Calixar 사는 막단백질 (GPCRs, Ion Channels, Transporters, Receptors, Anchors and Viral Proteins)의 원래 구조와 기능을 잘 보존하면서 분리하여 항체나 백신의 개발, 그리고 이를 활용한 새로운 치료 약물의 개발에 많은 도움을 주고 있는 이 분야 최고의 전문 기업입니다.

제품 특징

• Better Discovery
특정 형태에 얽매이지 않고 신뢰할 수 있고 효율적인 약물 및 항체 탐색

• Made for Pharma/Biotech
고품질 막 단백질로 제약, 생명 공학 회사 및 학술 팀의 응용 분야에 적합

• Any Life Science
Antibodies (Nanobodies, Scaffold proteins, Aptamers, Small molecules, 3D Structures

• Native Proteins
천연형, 야생형, 돌연변이 및 온전한 표적의 단백질 생산

• Proprietary Technology
고객을 위한 독점 기술과 전문성 제공 (7개의 특허군, 20개의 간행물)

• At any stage
모든 임상 단계에서 치료 약물 발견, 항체 개발 및 검증에 적합

Application

• Conformational antibody development
• Vaccine development
• High-throughput ligand screening
• Structure-based drug discovery
• Immunoassays
• Deorphanization projects
• Identification of relevant targets
• Expression of full-length membrane proteins
• Functional isolation and stabilization of targets

제품 사양

GPCR / A2A

GPCR / MT1 Transporter / AcrB
Transporter / BmrA Ion Channels / KCC2 Ion Channels / M2

GPCRs A2A MT1
Target name Adenosine receptor (A2A receptor) Melatonin receptor type 1A (MT1)
Catalogue number PP1 PP2
Class GPCR Class A GPCR Class A
Sequence Full-length, wildtype sequence, with a N-terminus Strep tag II, 8xHis-tag, and TEV
protease cleavage site.
Full-length, wildtype sequence, with a N-terminus Strep tag II, 8xHis-tag, and TEV
protease cleavage site.
Affinity Tag His/Strep (both N-terminal)​ Strepx2/His (both N-terminal)
Origin Human (Homo sapiens)​ Human (Homo sapiens)​
Theor. MW 47,7kDa 44,8kDa
Accession # P29274 (UniProt)​ P48039 (UniProt
Shipment temperature Dry Ice Dry Ice
Storage conditions Store at -80°C​ Store at -80°C​
Datasheet A2A-Datasheet.pdf MT1-Datasheet.pdf
Transporter AcrB BmrA
Target name Multidrug efflux pump subunit AcrB Multidrug resistance ABC transporter ATP-binding/permease protein (BmrA)
Catalogue number PP4 PP3
Class Multidrug efflux pump Multidrug resistance ABC transporter
Sequence Full-length, wildtype sequence, with a C-terminus, 6xHis-tag Full-length, wildtype sequence, with a N-terminus 6xHis-tag.
Affinity Tag His-tag (C-terminal) His-tag (N-terminal)
Origin Escherichia coli (strain K12) Bacillus subtilis (strain 168)
Theor. MW 114.6 kDa 64.5 kDa
Accession # P31224 (UniProt)​ O06967 (UniProt)​
Shipment temperature Dry Ice Dry Ice
Storage conditions Store at -80°C​ Store at -80°C​
Datasheet AcrB-datasheet.pdf BmrA-Datasheet.pdf
Ion Channels KCC2 M2
Target name Coming soon Coming soon
Catalogue number Coming soon Coming soon
Class Coming soon Coming soon
Sequence Coming soon Coming soon
Affinity Tag Coming soon Coming soon
Origin Coming soon Coming soon
Theor. MW Coming soon Coming soon
Accession # Coming soon Coming soon
Shipment temperature Coming soon Coming soon
Storage conditions Coming soon Coming soon
Datasheet Coming soon Coming soon

Document

제품 자료 A2A-Datasheet.pdf
MT1-Datasheet.pdf
AcrB-datasheet.pdf
BmrA-Datasheet.pdf
Upload date: 2021.10.07