Project Description
Anti-PEG Antibody
제품소개
폴리에틸렌 글리콜 (polyethylene glycol, PEG)는 인체 정맥내, 경구 및 피부 적용을 위해 FDA의 승인을 받은 무독성, 수용성, 생체 적합성 중합체입니다.
단백질, 펩타이드, 리포솜, 약물 및 나노입자에 PEG를 부착하면 약동학적 특성을 개선하고 면역원성의 가능성을 감소시킬 수 있습니다.
PEG는 일반적으로 동물과 사람에게 안전한 것으로 간주되지만, 큰 PEG를 빠르게 제거하지 못하면 지속적인 투여 후 조직에 PEG가 축적되어 잠재적인 부작용으로 인해 큰 문제를 나타내게 됩니다.
현재까지 20개 이상의 PEGylated protein, 펩타이드, 항체 조각, 올리고뉴클레오타이드가 연구 목적으로 FDA에 의해 승인되었습니다.
생물학 샘플에서 PEGylated compound의 정성 및 정량분석은 의약품 개발에 중요한 과정입니다.
Creative Diagnostics는 다양한 유형의 면역분석에서 활용 가능한 일련의 Anti-PEG 단일 클론 항체를 개발하였습니다.
이는 복잡한 매트릭스에서 PEG화된 표적 분자를 정량화하여 약물의 축적 정도를 모니터링하는 고품질 연구 도구로 활용할 수 있습니다.
Performance
| • Recognize PEG Conjugates and Free Form PEG. • Serve as Positive Controls for Drug Detection Assays. • Recommended antibody pair for sandwich ELISA (Capture-Detection): CABT-L3132 – CABT-L3133 DMABT-Z60567 – CABT-L3134 |
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주문정보
| Anti-PEG Antibodies List | |||
| Cat. No. | Product Name | Description | Application |
| DMABT-Z60095 | Rabbit Anti-PEG Mab, IgG, Biotin | Detects both linear and branched PEG. | IHC-P, ELISA, WB |
| DMABT-Z60369 | Rabbit Anti-PEG Mab, IgM | Binds to the PEG backbone. | WB, ELISA |
| DMABT-Z60567 | Rat Anti-PEG Mab, IgM | Displays high affinity to both short and long PEG molecules. | WB, ELISA |
| CABT-L3139 | Biotinylated DMABT-Z60567 | ||
| CABT-L3126 | Mouse Anti-PEG Mab, IgG1 | Detects repeating subunits present in PEG. | ELSIA, WB, IHC, FC |
| CABT-L3127 | Mouse Anti-PEG Mab, IgG1 | Binds to the PEG backbone. Detects PEGylated compounds. | ELSIA, WB, IHC |
| CABT-L3133 | Biotinylated CABT-L3127 | ||
| CABT-L3128 | Mouse Anti-PEG Mab, IgG1 | Detects backbone of PEG molecule. Detects PEGylated compounds. | ELISA, WB, FC |
| CABT-L3134 | Biotinylated CABT-L3128 | ||
| CABT-L3129 | Mouse Anti-mPEG Mab, IgG2b | Detects the terminal methoxy group of PEG. Suitable for detection of PEGylated liposomes and nanoparticles. | ELISA, WB, FC |
| CABT-L3136 | Biotinylated CABT-L3129 | ||
| CABT-L3130 | Rat Anti-PEG Mab, IgG2a | Detects PEGylated compounds. Higher affinity, Wider binding range than CABT-L3128. | ELISA |
| CABT-L3135 | Biotinylated CABT-L3130 | ||
| CABT-L3131 | Mouse Anti-PEG Mab, IgM | Binds to the PEG backbone, detects PEGylated compounds. | ELISA, WB, IHC, FC |
| CABT-L3137 | Biotinylated CABT-L3131 | ||
| CABT-L3132 | Mouse Anti-PEG Mab, IgM | Recognizes PEG backbone. Binds to PEGylated nanoparticles or long-chain PEGylated molecules. | WB, ELISA, IHC, FC |
| CABT-L3138 | Biotinylated CABT-L3132 | ||
| Human Anti-PEG Standards | |||
| CABT-L3140 | Chimeric Human Anti-PEG Mab, IgG1 | Fusion protein of mouse CABT-L3127 VH and VL with human IgG1. | |
| CABT-L3141 | Chimeric Human Anti-PEG Mab, IgM | Fusion protein of mouse CABT-L3132 VH and VL with human IgM. | |
| CABT-L3142 | Humanized Anti-PEG Mab, IgG1 | Recombinant antibody composed of humanized CABT-L3128 VH and VL with human IgG1 constant regions. | |
| Combination Packages | |||
| CABT-L3143 | Chimeric Anti-PEG Mab (Set) | This set contains 4 chimeric antibodies composed of the CABT-L3127 variable region genes fused to different human IgG constant domains (IgG1, IgG2, IgG3, and IgG4). | |
| CABT-L3144 | Chimeric Anti-PEG Mab (Set) | CABT-L3143; CABT-L3141. | |
| IgG Package 1 | Includes 100 µg of each clone | CABT-L3126; CABT-L3127; CABT-L3128; CABT-L3130; CABT-L3129. | |
| IgM Package 1 | Includes 100 µg of each clone | CABT-L3131; CABT-L3132; DMABT-Z60567. | |
| IgG Package 2 | Includes 100 µg of each clone | CABT-L3133; CABT-L3134; CABT-L3135; CABT-L3136. | |
| IgM Package 2 | Includes 100 µg of each clone | CABT-L3137; CABT-L3138; CABT-L3139. | |
Custom Antibody Labeling
We offer labeled antibodies using our catalog antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
관련정보
| 제품 자료 | Upload date: 2022.06.16 | |
| 제품 MSDS | ||
| 제품 메뉴얼 |