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Anti-PEG Antibody

제품소개

폴리에틸렌 글리콜 (polyethylene glycol, PEG)는 인체 정맥내, 경구 및 피부 적용을 위해 FDA의 승인을 받은 무독성, 수용성, 생체 적합성 중합체입니다.
단백질, 펩타이드, 리포솜, 약물 및 나노입자에 PEG를 부착하면 약동학적 특성을 개선하고 면역원성의 가능성을 감소시킬 수 있습니다.
PEG는 일반적으로 동물과 사람에게 안전한 것으로 간주되지만, 큰 PEG를 빠르게 제거하지 못하면 지속적인 투여 후 조직에 PEG가 축적되어 잠재적인 부작용으로 인해 큰 문제를 나타내게 됩니다.

현재까지 20개 이상의 PEGylated protein, 펩타이드, 항체 조각, 올리고뉴클레오타이드가 연구 목적으로 FDA에 의해 승인되었습니다.
생물학 샘플에서 PEGylated compound의 정성 및 정량분석은 의약품 개발에 중요한 과정입니다.

Creative Diagnostics는 다양한 유형의 면역분석에서 활용 가능한 일련의 Anti-PEG 단일 클론 항체를 개발하였습니다.
이는 복잡한 매트릭스에서 PEG화된 표적 분자를 정량화하여 약물의 축적 정도를 모니터링하는 고품질 연구 도구로 활용할 수 있습니다.

Performance

• Recognize PEG Conjugates and Free Form PEG.
• Serve as Positive Controls for Drug Detection Assays.
• Recommended antibody pair for sandwich ELISA (Capture-Detection):
CABT-L3132 – CABT-L3133
DMABT-Z60567 – CABT-L3134

주문정보

Anti-PEG Antibodies List
Cat. No. Product Name Description Application
DMABT-Z60095 Rabbit Anti-PEG Mab, IgG, Biotin Detects both linear and branched PEG. IHC-P, ELISA, WB
DMABT-Z60369 Rabbit Anti-PEG Mab, IgM Binds to the PEG backbone. WB, ELISA
DMABT-Z60567 Rat Anti-PEG Mab, IgM Displays high affinity to both short and long PEG molecules. WB, ELISA
CABT-L3139 Biotinylated DMABT-Z60567
CABT-L3126 Mouse Anti-PEG Mab, IgG1 Detects repeating subunits present in PEG. ELSIA, WB, IHC, FC
CABT-L3127 Mouse Anti-PEG Mab, IgG1 Binds to the PEG backbone. Detects PEGylated compounds. ELSIA, WB, IHC
CABT-L3133 Biotinylated CABT-L3127
CABT-L3128 Mouse Anti-PEG Mab, IgG1 Detects backbone of PEG molecule. Detects PEGylated compounds. ELISA, WB, FC
CABT-L3134 Biotinylated CABT-L3128
CABT-L3129 Mouse Anti-mPEG Mab, IgG2b Detects the terminal methoxy group of PEG. Suitable for detection of PEGylated liposomes and nanoparticles. ELISA, WB, FC
CABT-L3136 Biotinylated CABT-L3129
CABT-L3130 Rat Anti-PEG Mab, IgG2a Detects PEGylated compounds. Higher affinity, Wider binding range than CABT-L3128. ELISA
CABT-L3135 Biotinylated CABT-L3130
CABT-L3131 Mouse Anti-PEG Mab, IgM Binds to the PEG backbone, detects PEGylated compounds. ELISA, WB, IHC, FC
CABT-L3137 Biotinylated CABT-L3131
CABT-L3132 Mouse Anti-PEG Mab, IgM Recognizes PEG backbone. Binds to PEGylated nanoparticles or long-chain PEGylated molecules. WB, ELISA, IHC, FC
CABT-L3138 Biotinylated CABT-L3132
Human Anti-PEG Standards
CABT-L3140 Chimeric Human Anti-PEG Mab, IgG1 Fusion protein of mouse CABT-L3127 VH and VL with human IgG1.
CABT-L3141 Chimeric Human Anti-PEG Mab, IgM Fusion protein of mouse CABT-L3132 VH and VL with human IgM.
CABT-L3142 Humanized Anti-PEG Mab, IgG1 Recombinant antibody composed of humanized CABT-L3128 VH and VL with human IgG1 constant regions.
Combination Packages
CABT-L3143 Chimeric Anti-PEG Mab (Set) This set contains 4 chimeric antibodies composed of the CABT-L3127 variable region genes fused to different human IgG constant domains (IgG1, IgG2, IgG3, and IgG4).
CABT-L3144 Chimeric Anti-PEG Mab (Set) CABT-L3143; CABT-L3141.
IgG Package 1 Includes 100 µg of each clone CABT-L3126; CABT-L3127; CABT-L3128; CABT-L3130; CABT-L3129.
IgM Package 1 Includes 100 µg of each clone CABT-L3131; CABT-L3132; DMABT-Z60567.
IgG Package 2 Includes 100 µg of each clone CABT-L3133; CABT-L3134; CABT-L3135; CABT-L3136.
IgM Package 2 Includes 100 µg of each clone CABT-L3137; CABT-L3138; CABT-L3139.

Custom Antibody Labeling

We offer labeled antibodies using our catalog antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.

관련정보

제품 자료 Upload date: 2022.06.16
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